Tuesday, 18 November 2014

131 www. ajbrui. net Full length Research Article Blood Pressure Reducing Effect of Bitter Kola

131
www.
ajbrui.
net
Full length Research Article
Blood Pressure Reducing Effect of Bitter Kola
(
Garcinia
kola
,
Heckel
)
in Wistar Rats
Naiho A.O. &
*
Ugwu A.C.
Department of Physiology, Delta State University & University of Benin
ABSTRACT:
In this study the effect
of
Garcinia kola
(GK)
on blood pressure was investigated.
Albino wistar
rats were
divided into three groups
.
Groups A rats had normal rat chow and water ad
-
libitum while groups B and C rats had
Garcinia
kola
diet of 10% w/w and 15% w/w respectively, their
blood pressures were monitored weekly for a period of 6 weeks.
Secondly, inbred wistar rats weighing on the average 185g were anaestezized with thiopentone sodium 100mg/kg body weight
(b.wt) intraperitoneally and prepared for injection and for blood pressu
re measurements on a recording device (Ugo Basile
Itlay).
S
ignificant reduction in blood pressure (P<0.05) was observed in
rats given
G
K
-
enriched diets
,
in the third week. During
preliminary investigations it was observed that 5.0mg/kg b.wt dose of extract
was lethal after 6 minutes, while 3.0mg/kg b.wt
of the extract was tolerated for upwards of four hours. Based on these findings, graded doses of the extract. (0.5
3.0mg/kg)
were used and these doses produced statistically significiant (P<0.05) fall in m
ean arterial pressure and also significant
(P<0.05) increase in heart rate. Cholinergic blockade produced no significant attenuation on the effect of extract. However
there was a significant (P<0.05) attenuation to extract effect after Histaminergic blocka
de. This study shows that
Garcinia kola
contains in its alcohol extract, a v
a
soactive substance that has a blood pressure reducing effect.
KEY WORDS:
blood pressure,
Garcinia kola
, Vasoactive, Heart rate
INTRODUCTION
1
These agents usually act through electrical or non
-
electrical pathways. It is known that agents such as
Hypertensive disorders are the m
ost common causes of
adult morbidity and mortality in Africa. Many workers
have discovered many vasoactive substances capable of
reducing blood pressure. These include studies on the
blood pressure lowering ability of some natural plant
materials, such as
extracts of garlic, seed of pawpaw
(carica papaya), calyx of hibiscus and petals of
hibiscus.
Vasoactivie agents are considered to be any
physiologically occurring or exogenously administered
hormonal substance that alters the activity of vascular
smooth
muscle i.e. that cause its contraction, relaxation,
or both. (Bohr et al 1979).
1
Address for correspondence (
acugwu@yahoo.com
)
acetylcholine, alters membrane permeability and hence
change the net
diffusion potential, hyperpolarizing the
membrane and bringing about relaxation of vascular
smooth muscles (Nakajima and Hom 1967).
Cholingergic agents, also alters the frequency and other
characteristics of the action potential and these
alterations cause
changes in the mechanical
performance of the portal vein (Von Loh, 1971). The
cyclic AMP pathway is another process by which some
vasodilators bring about relaxation of vascular smooth
muscle supportive of this mechanism and this is
because the fact that
cyclic AMP itself, causes
vasodilatation. Anderson (1992) has presented
extensive evidence that suggest cyclic AMP stimulates
an energy requiring Ca
2+
binding mechanism that leads
to a decreased concentration of sarcoplasmic calcium,
and hence relaxation.
G
arcinia kola, known as
“false” kola, belongs to
the order of guterferae and contains pharmacologicall

bitter kola

Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation.

0 comments:

Post a Comment

 

Copyright @ 2013 BitterKolaCompany.